Course: Cell Biology: Mitochondria
Instructors: Robert A. Lue
Quote:We will focus, in particular, on the mitochondrion, the organelle that powers the cell. In this context, we will look at the processes of cell metabolism. Finally, we will examine the F1F0 ATP synthase, the molecular machine that is responsible for the synthesis of most of the ATP that your cells require to do work. To underscore the importance of cell biology to our lives, we will address questions of development and disease and implications of science in society.
How much you get from this course probably depends on where you’re starting from, but for me, with one basic bio course and a couple of introductory chems, it was at just the right level. And beautiful: take a look at the teaser video for the course. The animations are terrific, and while it’s possible to learn the material from simple pencil drawings, I always appreciate creativity and style. But it goes beyond aesthetics; it’s memorable, which makes it understandable beyond memorizing words. I can recall NADH reducing Complex II which is then oxidized by Coenzyme Q, while using the energy from the internal redox reactions to pump protons against the concentration gradient, because I can “see” the process happening in my head. Beyond the visual component, the lectures were clear; the quiz and exam questions required thought and combinations of concepts and thus tested understanding rather than the ability to look up factual information. As the icing on the cake, the forum was active with both students and staff providing helpful clarifications.
The first couple of weeks were for me mostly review material on overall cellular biology topics I’d seen in the archived (inactive) MIT Intro to Biology course (the chem courses I’ve taken were helpful as well in understanding bonds and redox reactions). But since I’m still very new to all of this, I like going through it from a slightly different angle which emphasizes different points. Material on endosymbiosis included a wonderful video by paper-cut artist Andrew Benincasa (it’s available at his website if you’re curious why I’m so impressed; his other vids are well worth watching too). There was a fair amount of material on mitochondrial disease, something I’d never heard of before (three-way IVF? Who knew?). In addition to the biology, the human element was part of the presentation through one woman’s very personal story.
In weeks 3 and 4, mitochondria got real. We went into glycolysis, the citric acid cycle, ECT, and the grand finale, ATP synthesis, in significant detail. The idea was not to delve into the atomic level of chemical reactions, but to understand how interrupting the process at any given stage would affect various parameters like oxygen consumption or ATP production, and how those parameters might be measured. It was complicated, with a need to see not just the step-by-step but the overall process. I can’t say I’m an expert, but I could reason my way through the final so the educational methodology worked and I have enough of a foundation to keep going.
I hope I do get to keep going. I hope this is the first in a series of cell biology courses. In addition to being a molecular/cellular biologist and a very good teacher, Prof. Lue is director of HarvardX, which includes the mooc division, so I’m hoping he has more up his sleeve.