Course: Biochemistry: Biomolecules, Methods, and Mechanisms
Length: 12? weeks, 3-6? hrs/wk
Instructor: Michael Yaffe
Quote:We developed 7.05x Biochemistry with an emphasis on:
• Developing your scientific thinking skills including articulating hypotheses, performing thought experiments, interpreting data, and designing experiments.
• Using data based on real scientific experiments and highlighting the scientific process.
• Asserting that biology is an active field that changes daily through examples of MIT (and other current) research, not static information in a textbook.
• Visualizing real molecular structures with PyMOL to better understand function and mechanism.
• Appreciating the quantitative aspects of biochemistry and practicing this quantitation with MATLAB.
• Translating topics in biochemistry to diseases and medicine.
• Conveying the authentic MIT firehose experience.
• Implementing the science of learning in the course design.
I started to take this course a couple of years ago, and ran away screaming when I saw it started with “Buffers and pH.” For some reason I felt more up to it at this point, though I haven’t done any additional work on those topics. Predictably, I did quite poorly on that unit – and a couple of other units – but it was still very worthwhile.
MIT’s biology department emphasis is always on the practical approach. That is, they go through a pathway or a process in detail, give you a couple of general questions to see if you’ve got the idea, then throw you into a story set in a lab and make you figure out the setup: what assay do you need, what product are you looking for, what reactants do you need, what would you expect to see, what does this result – graph, gel image, whatever – mean. This is, after all, what biochemists are training for, not memorizing reactions. Something I discovered late in the course: the names of the fictional lab team in the Problem Set questions are the names of biochemists. They don’t have the distinct (and amusing) personalities of those in the Molecular Bio lab scenarios, but it’s still a great approach.
The home page emphasize some prior biology is needed to succeed. As usual, I needed more (any?) organic chem in some places; they do provide a nice set of review materials on pertinent topics – orbitals, thermodynamics, functional groups – and that helped.
The material is broken down into eight modules, one released every week, but the due dates allow a week of extra time for all modules. I wish I had the chops to spend just 3 to 6 hours as predicted on the home page; for me, it was more like 10 – 12 hours, though I do a lot of extra work basically copying the whole course into a Word document for future reference. Each module consists of a set of between ten and twenty video lectures; these are each followed by a short quiz that allows unlimited attempts for each question. The module is capped off by a Problem Set, where the number of attempts are more restricted and the lab scenario is usually prominent. As you might expect, the Problem Sets count for a lot more than the Test Yourself quizzes. Some weeks have far more material than others, but it might be they seemed harder to me because they hammered my weaknesses.
Some of the Problem Sets included questions that required the use of MatLab; you can connect for free through the course (in fact I still had an account from a prior course, to my surprise). I skipped these entirely. Maybe another time. Optional PyMol assignments were also included. I used PyMol in another course, and liked it a lot, but I didn’t mess with it this time; I had too much to deal with already.
Then there’s the “final”, in the form of what they call a Competency Exam (paywalled; $150). Don’t worry if you can’t or don’t want to pay the fee; there’s plenty of testing throughout to make sure you’ve got the salient points. I’m perfectly happy with the free material available, even if I do have a score of only 26% to show for my trouble. The bright side is, the maximum could only be 30%, so if I look at it one way, I got a score of 86%. I suspect the Competency Exam is significantly harder (they call it a challenge), it’s timed (oh no…), and it would have required a review of all the material (and I was pretty much done by the time I finished the last problem set) so I’m fine with not paying $150 for the work and likely humiliation.
I’m a big fan of MIT’s approach, even though I’ll never set foot in a bio lab or work on an actual science degree. The Harvard Biochem mooc is, after the thermodynamic component, more about specific pathways, particularly the generation, metabolism, and regulation of major elements, and the testing is far more information-retrieval. I might take that again, because that’s fun, too. And I feel more up to the thermodynamics and kinetics material, thanks to this course.