Course: Fundamentals of Immunology: Death by Friendly Fire
Length: 5 weeks
Instructors: Alma Moon Novotny
In this biology and life sciences course, we’ll flip the basic question of, “How does the immune system protect you?” to, “How can your immune system endanger you?”
First, we will look at basic mechanisms that determine whether the immune system is roused to action or instructed to stand down, including the roles of inflammasomes and T regulatory cells and the results of mutation to genes and their importance in producing regulatory proteins. Then, we will apply these insights to explain the etiology and treatment of autoimmune diseases and look at a variety of misdirected immune attacks, including allergies, attacks on red blood cells and cellular responses that can produce damage ranging from rashes to autoimmune cellular destruction. Finally we will discuss the protection of transplants from an immune system that views them as foreign invaders instead of necessary replacements.
Short version: Good course, covering a lot of ground (with some unique flair) in a very short time. It’s the third in an Immunology series from Rice. I’d missed the first two, so I spent a couple of weeks getting up to speed on the basics. I had most of the essential vocabulary and some understanding of what was going on – innate vs. acquired, MHCs, opsonisation, even some understanding of the complement cascade leading to MAC attack though I didn’t get to the point of memorizing the pathways – but still ended up scrambling for a lot of detail I seem to have overlooked. On the plus side, I’ve done enough medical reading to be perfectly comfortable with the overall physiological mechanisms of myasthenia gravis and lupus etc., so until we got to which cytokines or antibodies or receptors were involved, I could relax for a while. I passed with room to spare, but I wouldn’t say I’m secure in the subject. It’s more like I understand the general outline of what’s involved, and I now have the background to nail down the details more firmly. But for a free 4-week course, that’s plenty.
The four content weeks covered tolerance (how our immune systems learn to tell the difference between what’s dangerous and what’s not), autoimmune disease, hypersensitivities, and transplant issues. Each week included practice questions and a weekly exam, and some weeks had review exams of prior material (a terrific idea; I wish more courses did this). Week 5 was for self-review and the final exam.
The lectures included clever drawings of various immune system cells coded with their distinguishing characteristics: what receptors they carry, what they upregulate, downregulate, or bind to, what features they’re armed with. Other illustrations provided good support to the lectures as well, though I went hunting for some of my own personal favorites on antibody structure and MHC genetics. We all have our favorite diagrams. If I’d taken the first two courses before this one (like you’re supposed to), I might’ve not needed the extra visuals.
All exams were multiple choice; the weekly exams allowed three chances to answer. I’m usually pretty dismissive of that kind of thing, but the questions were very well-designed: some information retrieval things (they called them “factoids”) but lots of “thinking” questions that required analysis or synthesis of information in light of the concepts presented. Sometimes the question structure itself was a little weird, but it’s all about being able to manipulate the material. The final exam was also multiple choice, but allowed only one try, and counted for 50% of the grade, so guessing doesn’t work as an overall strategy (not that I’ve ever understood why anyone would bother to fake his way through a mooc, but it happens). I loved that the 40-question final was broken down in to 8 parts of 5 questions each. Not only is it less likely to trigger panic (oh my god, look at all these questions, how will I ever do them all?!?), but it forces kind of mini-reviews along the way.
The forums were active and staff, including Prof. Novotny, were available to answer questions that went a bit beyond the material (like, Hey, do animals also have a sex differential in autoimmune disease frequency? Yes, yes they do, in fact. That seems significant to me for some reason). There were a few minor first-run glitches: edX opened more of the system than they were supposed to in the Week 0 period, intended only for review of the outlines from the previous two courses (which, as someone who didn’t take the earlier courses, I found helpful, but nowhere near sufficient as preparation for this segment, by the way). They did an admirable job keeping up with unexpected but eager hordes of students flooding the forums before staff was in place. A few answer-coding problems cropped up throughout the course in ungraded sections. But overall, the execution was great. They really put a lot of thought into the images used, and I found it helpful in remembering what roles individual cells played in the immune process.
I was quite pleased with this course. It’s a nice balance of detailed molecular interactions and general clinical features, done with creativity and humor. I also have become a big fan of the immune system. I’ve had these vague notions of B cells and T cells, but I’m always amazed, whenever I take a biology course, that anything ever works – do you know how many millions of things have to happen for you to just go on living? – and the interactions of all the moving parts are fascinating. I’m eager to take the first two courses when they roll around again (and possibly retake this one, since I’ll be much better prepared). I understand there’s also a fourth part coming, The Immune System Fights Back. That sounds like fun.